{"id":1566,"date":"2024-01-12T11:39:23","date_gmt":"2024-01-12T16:39:23","guid":{"rendered":"https:\/\/mote.org\/?post_type=program&#038;p=1566"},"modified":"2026-01-08T11:09:16","modified_gmt":"2026-01-08T16:09:16","slug":"marine-biomedical-research","status":"publish","type":"program","link":"https:\/\/mote.org\/research\/program\/marine-biomedical-research\/","title":{"rendered":"Marine Biomedical Research"},"content":{"rendered":"<p><iframe title=\"Mote Marine Laboratory Biomedical Research\" width=\"640\" height=\"360\" data-src=\"https:\/\/www.youtube.com\/embed\/nXdoYA7AzXk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" data-load-mode=\"1\"><\/iframe><\/p>\n<p>The Marine Biomedical Research Program focuses on basic and applied research using sharks, skates, and stingrays as laboratory animal models. Areas of interest include biochemistry, physiology, immunology, reproductive biology and embryonic development.<\/p>\n<p>Major research efforts in the program are directed at understanding the remarkable overall health of sharks and their skate and ray relatives, including studies to investigate their low incidence of disease, including cancer, and their relatively rapid and infection-free healing of wounds . The ultimate goal is to use results from these studies to contribute to a better understanding of health problems in higher animals, including humans, and to benefit the wild populations of the particular organisms studied.<\/p>\n\n    <div class=\"gallery gallery-columns-4\">\n                                <figure class=\"gallery-item\">\n                <div class=\"gallery-icon\">\n                                        <a href=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_036W-2048x1365.jpg\" data-fancybox=\"gallery\" data-caption=\"\">\n                                            <img decoding=\"async\" class=\"featured-image lazyload  \" src=\"https:\/\/mote.org\/wp-content\/themes\/mote\/src\/images\/dummy.png\" data-src=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_036W-1024x683.jpg\" srcset=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_036W-1024x683.jpg 1024w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_036W-300x200.jpg 300w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_036W-768x512.jpg 768w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_036W-1536x1024.jpg 1536w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_036W-2048x1365.jpg 2048w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_036W-1920x1280.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" alt=\"\"  \/>                                        <\/a>\n                                    <\/div>\n                            <\/figure>\n                                <figure class=\"gallery-item\">\n                <div class=\"gallery-icon\">\n                                        <a href=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_064W-2048x1365.jpg\" data-fancybox=\"gallery\" data-caption=\"\">\n                                            <img decoding=\"async\" class=\"featured-image lazyload  \" src=\"https:\/\/mote.org\/wp-content\/themes\/mote\/src\/images\/dummy.png\" data-src=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_064W-1024x683.jpg\" srcset=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_064W-1024x683.jpg 1024w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_064W-300x200.jpg 300w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_064W-768x512.jpg 768w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_064W-1536x1024.jpg 1536w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_064W-2048x1365.jpg 2048w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_064W-1920x1280.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" alt=\"\"  \/>                                        <\/a>\n                                    <\/div>\n                            <\/figure>\n                                <figure class=\"gallery-item\">\n                <div class=\"gallery-icon\">\n                                        <a href=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_077W-2048x1365.jpg\" data-fancybox=\"gallery\" data-caption=\"\">\n                                            <img decoding=\"async\" class=\"featured-image lazyload  \" src=\"https:\/\/mote.org\/wp-content\/themes\/mote\/src\/images\/dummy.png\" data-src=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_077W-1024x683.jpg\" srcset=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_077W-1024x683.jpg 1024w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_077W-300x200.jpg 300w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_077W-768x512.jpg 768w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_077W-1536x1024.jpg 1536w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_077W-2048x1365.jpg 2048w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_077W-1920x1280.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" alt=\"\"  \/>                                        <\/a>\n                                    <\/div>\n                            <\/figure>\n                                <figure class=\"gallery-item\">\n                <div class=\"gallery-icon\">\n                                        <a href=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_068W-2048x1365.jpg\" data-fancybox=\"gallery\" data-caption=\"\">\n                                            <img decoding=\"async\" class=\"featured-image lazyload  \" src=\"https:\/\/mote.org\/wp-content\/themes\/mote\/src\/images\/dummy.png\" data-src=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_068W-1024x683.jpg\" srcset=\"https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_068W-1024x683.jpg 1024w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_068W-300x200.jpg 300w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_068W-768x512.jpg 768w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_068W-1536x1024.jpg 1536w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_068W-2048x1365.jpg 2048w, https:\/\/mote.org\/wp-content\/uploads\/2024\/01\/BiomedicalImmunologyStingrayResearch_20170214_068W-1920x1280.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" alt=\"\"  \/>                                        <\/a>\n                                    <\/div>\n                            <\/figure>\n            <\/div>\n\n    \n<p>&nbsp;<\/p>\n<h2>Program Details<\/h2>\n<div class=\" bsd-accordion\" id=\"1\"><div class=\"card\"><div class=\"card-header\" id=\"heading-card-0-0\">\n                    <span data-toggle=\"collapse\" data-target=\"#card-0-0\" aria-expanded=\"true\" aria-controls=\"card-0-0\">\n                    Current Projects\n                    <span class=\"accordion-icon\"><\/span>\n                    <\/span>\n            <\/div>\n            <div id=\"card-0-0\" class=\"collapse \" aria-labelledby=\"heading-card-0-0\" data-parent=\"#1\">\n                <div class=\"card-body\">\n                    <ul>\n<li>Cytotoxic factors produced by cultured shark immune cells: This project\u2019s goal is to isolate and characterize the bioactive factors that are produced by short-term cultures of shark immune cells. Mote studies have shown that these immune-cell derived factors can inhibit the growth of human tumor cell lines. Studies also focus on understanding the cellular pathways activated by these factors that result in tumor cell death. This project is in collaboration with Dr. Cathy Walsh of Mote\u2019s Marine Immunology Program and Dr. A.B. Bodine at Clemson University. The project is funded by the Henry L. and Grace Doherty Charitable Foundation, a Florida High Tech Corridor Industry Seed Grant, and numerous matching grants.<\/li>\n<li>Novel antimicrobial compounds from epidermal mucus: This project is looking at the microbial makeup of the epidermal mucus produced by stingrays in order to determine whether the mucus contains antibiotic properties that could be used in human health applications. Dr. Luer is the lead investigator on this multi-institution project that includes Mote scientists (co-investigators Dr. Cathy Walsh, Marine Immunology, Dr. Kim Ritchie, Marine Microbiology Program), Daemen College (Dr. Laura Edsberg; Dr. Jennifer Wyffels), USF Center for Biological Defense (Dr. Andy Cannons, Dr. Vicki Luna) and Clemson University (Dr. A.B. Bodine). The project is funded by the U.S. Department of Defense.<\/li>\n<li>Wound healing in stingrays: This project is using controlled experimental wounding to characterize the healing process of wounds penetrating the epidermal and dermal layers of skin in stingrays. Anecdotal reports of relatively rapid and infection-free healing of wounds in sharks and rays are common, yet studies to characterize the healing process are rare. This project is in collaboration with Dr. Cathy Walsh of Mote\u2019s Marine Immunology Program and Dr. Laura Edsberg and Dr. Jennifer Wyffels at Daemen College. The project is funded by the U.S. Department of Defense.<\/li>\n<\/ul>\n                <\/div>\n            <\/div>\n        <\/div><div class=\"card\"><div class=\"card-header\" id=\"heading-card-0-1\">\n                    <span data-toggle=\"collapse\" data-target=\"#card-0-1\" aria-expanded=\"true\" aria-controls=\"card-0-1\">\n                    Grants Received\n                    <span class=\"accordion-icon\"><\/span>\n                    <\/span>\n            <\/div>\n            <div id=\"card-0-1\" class=\"collapse \" aria-labelledby=\"heading-card-0-1\" data-parent=\"#1\">\n                <div class=\"card-body\">\n                    <p><strong>Project Title: Shark Immune Cell-Derived Peptides as Novel Agents for Cancer Therapy<\/strong><br \/>\nGranting Organization: Henry L. and Grace Doherty Charitable Foundation, plus matching support from numerous private foundations, charitable trusts, and private individuals<br \/>\nProject PI\u2019s: Carl Luer, Cathy Walsh<\/p>\n<p><strong>Project Title: Tumor Cell Inhibitory Activity of Compounds Isolated from Culture Medium of Shark Immune Cells<\/strong><br \/>\nGranting Organization: Florida High Tech Corridor Industry Seed Grant Program<br \/>\nProject PI\u2019s: Carl Luer, Cathy Walsh<\/p>\n<p><strong>Project Title: Novel Compounds from Stingray Epidermal Mucus With Antimicrobial Activity Against Wound Infection Pathogens<\/strong><br \/>\nGranting Organization: U. S. Department of Defense<br \/>\nProject PI\u2019s: Carl Luer, Cathy Walsh, Kimberly Ritchie, AB Bodine, Laura Edsberg, Jennifer Wyffels, Andrew Cannons, Vicki Luna<\/p>\n                <\/div>\n            <\/div>\n        <\/div><div class=\"card\"><div class=\"card-header\" id=\"heading-card-0-2\">\n                    <span data-toggle=\"collapse\" data-target=\"#card-0-2\" aria-expanded=\"true\" aria-controls=\"card-0-2\">\n                    Research Collaborations\n                    <span class=\"accordion-icon\"><\/span>\n                    <\/span>\n            <\/div>\n            <div id=\"card-0-2\" class=\"collapse \" aria-labelledby=\"heading-card-0-2\" data-parent=\"#1\">\n                <div class=\"card-body\">\n                    <ul>\n<li>Clemson University Department of Animal and Veterinary Sciences, Clemson, SC (A. B. Bodine, PhD)<\/li>\n<li>Daemen College Center for Wound Healing Research, Amherst, NY (Laura Edsberg, PhD and Jennifer Wyffels, PhD)<\/li>\n<li>University of South Florida Center for Biological Defense, Tampa, FL (Andrew Canons, PhD and Vicki Luna, PhD)<\/li>\n<li>University of North Florida, Jacksonville, FL (James Gelsleichter, PhD)<\/li>\n<li>H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL (John Koomen, PhD)<\/li>\n<li>Rhode Island College, Providence, RI (Rebeka Merson, PhD)<\/li>\n<li>Mount Desert Island Biological Laboratory (MDIBL), Salisbury Cove, ME (Benjamin King)<\/li>\n<li>All Children&#8217;s Hospital\/University of South Florida Children\u2019s Research Institute, St. Petersburg, FL (Gary Litman, PhD)<\/li>\n<li>Florida Atlantic University, Department of Biological Sciences, Boca Raton, FL (Stephen Kajiura, PhD)<\/li>\n<\/ul>\n                <\/div>\n            <\/div>\n        <\/div><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"featured_media":5956,"parent":0,"menu_order":0,"template":"","areas-of-research":[14],"research-program-type":[1039],"class_list":["post-1566","program","type-program","status-publish","has-post-thumbnail","hentry","areas-of-research-biomedical-technology-development","research-program-type-mote-research-programs"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Marine Biomedical Research | Mote Marine Laboratory &amp; Aquarium<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mote.org\/research\/program\/marine-biomedical-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Marine Biomedical Research | Mote Marine Laboratory &amp; Aquarium\" \/>\n<meta property=\"og:description\" content=\"The Marine Biomedical Research Program focuses on basic and applied research using sharks, skates, and stingrays as laboratory animal models. 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